Sickle cell anemia and the sickling phenomenon are generally considered to be found only in Negroes or in persons having an admixture of Negro blood. A review of the literature, however, shows reports of several cases in which the possibility of Negro blood in the patient is remote.
Archibald1 reported a case of sickle cell anemia in an Arab, and Stewart2 reported one in a Cuban; in neither could the possibility of Negro blood be excluded. On the other hand, Castana3 reported a case of sickle cells in an Italian child, and Cooley and Lee4 reported a typical case in a Greek child, in whom the possibility of Negro blood was improbable. Rosenfeld and Pincus5 described an instance of a child of Mediterranean parentage with sickle cell anemia, in whom the presence of Negro blood was not possible, as the family had lived in the
WALLACE SA, KILLINGSWORTH WP. SICKLEMIA IN THE MEXICAN RACE. Am J Dis Child. 1935;50(5):1208-1215. doi:10.1001/archpedi.1935.01970110116016