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February 1936

EFFECTS ON THE FETUS OF HYPERVITAMINOSIS D AND CALCIUM AND PHOSPHORUS DEFICIENCY DURING PREGNANCYLESTER WARREN SONTAG, M.D.

Author Affiliations

YELLOW SPRINGS, O.

Am J Dis Child. 1936;51(2):302-310. doi:10.1001/archpedi.1936.01970140066007
Abstract

The experiment described in this paper was undertaken in an attempt to shed additional light on the relationship between abnormalities of the intake of minerals and of vitamin D by the mother and the mineralization of the rat fetus. Specifically, we wished to know whether: (1) mineral deficiency of the mother during gestation results in a demonstrable mineral deficiency in the fetus; (2) maternal mineral deficiency not severe enough to show osteoporosis in a roentgenogram could affect fetal mineral metabolism; (3) demineralizing effects of hypervitaminosis D, such as those observed by Harris in young rats on a diet low in calcium and phosphorus, were apparent in the offspring of rat mothers who were similarly maintained; (4) vitamin D in therapeutic doses administered to pregnant rats being maintained on a diet deficient in calcium and phosphorus would change materially the mineral content of the fetus. The effects on the developing fetus

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