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Case Reports
September 1936

MACROCYTIC HYPERCHROMIC ANEMIA IN EARLY INFANCYREPORT OF A CASE AND REVIEW OF THE LITERATURE

Author Affiliations

NEW YORK
From the Pediatric Service of Dr. C. S. Boyd, the New York City Hospital, Welfare Island.

Am J Dis Child. 1936;52(3):633-647. doi:10.1001/archpedi.1936.04140030123011
Abstract

During the past two decades exhaustive investigation has helped clarify many phases of the problem of infantile anemia. Deficiency and hemolytic anemia have been rather definitely differentiated, and each type in turn has been subdivided in an attempt to analyze further and to understand the pathogenesis involved. Investigations of microcytic hypochromic anemia have been comparatively thorough, probably because of its great frequency. On the other hand, the macrocytic hyperchromic type of deficiency anemia has been less completely studied, owing to its comparative rarity. In this paper a case of macrocytic hyperchromic anemia in an infant aged 9 months is reported, and the literature on similar anemia in patients under 1 year of age is reviewed.

REVIEW OF THE LITERATURE  Reports of cases of macrocytic hyperchromic anemia in early infancy have been scanty. Indeed, Blackfan,1 Cooley and Lee,2 Naegeli3 and others stated the belief that pernicious (Addison-Biermer's) anemia

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