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October 1936

SECOND ATTACKS OF POLIOMYELITIS IN MACACUS RHESUS MONKEYS

Author Affiliations

CLEVELAND
From the Department of Pediatrics, Western Reserve University, and the Division of Contagious Diseases, City Hospital.

Am J Dis Child. 1936;52(4):802-809. doi:10.1001/archpedi.1936.04140040032004
Abstract

During the past three years seventy-one Macacus rhesus monkeys were given injections of combinations of poliomyelitis virus either into the subserosa or into the small intestine, between clamps placed in a manner previously described.1 In thirteen of the animals quadriplegia developed, and all but one died. Seven showed merely a fleeting muscular weakness, while each of the remaining fifty-one monkeys had obvious monoparesis or monoplegia, paraparesis or paraplegia or a combination of both. After recovery fifteen of the fifty-one animals had atrophy of some group of muscles, which in most instances was limited to one leg.

A study is in progress of the pathologic changes that occurred in the central nervous systems of the Macacus rhesus monkey after the introduction of poliomyelitis virus by way of the gastro-intestinal tract, and the observations will be given in detail later.2 In passing, however, it can be said that in the

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