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January 1937

CHANGES IN THE GROWING SKELETON AFTER THE ADMINISTRATION OF BISMUTH

Author Affiliations

NEW YORK
From the Department of Diseases of Children, Columbia University College of Physicians and Surgeons, and the Babies Hospital.

Am J Dis Child. 1937;53(1_PART_I):56-78. doi:10.1001/archpedi.1937.04140070065005
Abstract

In a previous discussion of the skeletal changes in lead poisoning, I1 commented on the possibility that other heavy metals might produce similar alterations in growing bones. At that time, however, I had not seen comparable lesions in the roentgenograms of infants and children who had received bismuth in antisyphilitic treatment. More recent observations have revealed shadows in the skeletal roentgenograms of such patients similar to "lead lines." In addition, I have since had an opportunity to study roentgenologically and histologically the lesions in the bones of growing dogs after the intramuscular injection of bismuth.

ROENTGENOLOGIC FINDINGS FOR INFANTS AND CHILDREN  Four types of lesion have been selected to illustrate the bismuth changes which follow syphilitic therapy: (1) the lesion which occurs directly after a single course of treatment with bismuth; (2) that which occurs many weeks after a single course; (3) that which occurs after multiple courses during

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