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January 1937


Author Affiliations

Department of Pediatrics, Western Reserve University School of Medicine, and Division of Contagious Diseases, City Hospital CLEVELAND; Department of Anatomy, Ohio State University College of Medicine COLUMBUS, OHIO

Am J Dis Child. 1937;53(1_PART_I):79-88. doi:10.1001/archpedi.1937.04140070090006

For some time after the virus of poliomyelitis is injected intracerebrally into Macacus rhesus monkeys, there is no histologic evidence of its presence. The inflammatory reaction that is seen to occur immediately after the intracerebral injection is not specific. It can be explained as a local reaction about an irritating foreign body. Fair-brother and Hurst1 showed that four days elapsed after the intracerebral injection of the virus before they could demonstrate its presence in the cords of Macacus rhesus monkeys. At the end of the same period the animals began to show symptoms. Faber2 noted the spread of virus down the cord and demonstrated its presence at several points in the central nervous system by injecting suspensions of virus taken from various areas of the cord into other animals. Clearly, transfer experiments may show the presence of a virus even in the absence of histologic changes. There is

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