This is a report of an epidemic of measles at the Israel Orphan Asylum in which one group of children was treated with human immune globulin while the other was held as a control. Before reporting our observations, it will be interesting to review briefly the history of measles.
Rhazes1 in the ninth century described an eruptive disease typical of measles, under the name of hhasbah. Many observers during the four-teenth, fifteenth and sixteenth centuries described the disease, calling it morbilli or bluccia. They were, however, unable to differentiate other macular lesions and eruptive fevers from measles. The first indisputable record of a true epidemic of measles was reported by Forest1 in 1563. More accurate clinical and scientific knowledge of the epidemic form of measles was furnished by Sydenham and Morton1 in 1670 and 1674. But not until the latter part of the eighteenth century and the
GOLDSTEIN H, EISENOFF HM, BLAUNER SA. USE OF IMMUNE GLOBULIN IN THE PROPHYLAXIS OF MEASLES. Am J Dis Child. 1937;53(1_PART_I):110-116. doi:10.1001/archpedi.1937.04140070121008