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This monograph presents a comprehensive discussion of the clinical and hematologic problems offered by leukemia (the leukoses) in children. The discussion is based on the histories of 50 cases of leukosis observed by the author and of 492 cases reported in the literature. The author follows Nägeli's concept of the dual nature of the disease and considers the lymphadenoses and myeloses. He differs from Nägeli on a few points of hematologic interest. Nägeli expressed the belief that blood cells are derived from the primitive mesenchyme cell, which produces the proerythroblast, the lymphoblast and the myeloblast, and that these forms are the forerunners of the mature elements of the blood. He stated that granular leukocytes, monocytes and megakaryocytes are derived from the myeloblast. He was of the opinion that in leukemia the myeloblast may produce a pathologic cell, the paramyeloblast, which is the common cell of leukemia. Analogous to the paramyeloblast
Die Leukosen im Kindesalter.. Am J Dis Child. 1937;53(2):662-663. doi:10.1001/archpedi.1937.04140090235015