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September 1937


Author Affiliations

From the Department of Pediatrics, Harvard University Medical School, and the Infants' and the Children's Hospitals, Boston.

Am J Dis Child. 1937;54(3):496-503. doi:10.1001/archpedi.1937.01980030040002

Since the original work of Rosenheim on the use of mandelic acid in the treatment of urinary infections1 was reported, a few additional series of cases have been recorded.2 The keen thought which fostered Rosenheim's experiments and the logical way in which they were pursued are worth mention. Prompted by Fuller's demonstration that the effective bactericidal agent produced by the ketogenic diet is betahydroxybutyric acid,3 Rosenheim examined a considerable number of chemically similar substances in search for one which would exhibit the following characteristics: (1) nontoxicity when taken by mouth, (2) excretion in the urine in an unchanged condition and (3) bactericidal action in the urine. Mandelic acid (or its sodium salt) was the one chemical examined which fulfilled all of these requirements. Because of the favorable results reported in the three series of cases to which reference has been made, it has seemed desirable to extend

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