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December 1938

ALTERED LIPID METABOLISM IN ACUTE INFECTIONS OF INFANTS AND OF OLDER CHILDREN

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics, the University of Minnesota.

Am J Dis Child. 1938;56(6):1215-1230. doi:10.1001/archpedi.1938.01980180029002
Abstract

In previous communications1 has been reported the influence of acute infections on the plasma lipid values of children ranging in age from infancy to 14 years. There was definite lowering of the values for total cholesterol, for total fatty acids and for phospholipids at the height of the disease as compared with the levels during convalescence. Diet had no demonstrable influence. Fever per se was not responsible for the lowering of the various lipid constituents of the blood plasma. Since experiments on animals have already shown that the lipids are involved in some way in the phenomena of immunity, further studies were made in order to furnish data which might be of value in more complete investigations into the chemistry of immunity. An analysis was made of the changes which occur in the free cholesterol and in the cholesterol esters and of the variations in the degree of unsaturation

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