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December 1938


Author Affiliations

From the Department of Pediatrics, New York University, and the Children's Medical Service of Bellevue Hospital. This study has been made under a grant of the Milbank Foundation. Dr. Robert M. Lewis was closely associated with the work.

Am J Dis Child. 1938;56(6):1242-1247. doi:10.1001/archpedi.1938.01980180056004

On the suggestion that the gonococcus was one of the organisms susceptible to sulfanilamide, it was decided to treat gonorrheal vaginitis in children by oral administration of sulfanilamide in further search for a simple and effective method of handling this therapeutic problem. After encouraging results had been obtained in cases of vaginitis, sulfanilamide was applied to the treatment of gonorrheal urethritis in boys and of gonorrheal conjunctivitis.

This report summarizes the results of treatment with sulfanilamide in 9 cases of conjunctivitis, in 5 cases of urethritis in boys and in 22 cases of vaginitis in girls since May 1937.

Diagnosis of gonococcic infection was made on the basis of the finding of gram-negative intracellular diplococci, morphologically typical of gonococci, in smears from the eyes, urethra or vagina. Gonococcic complement fixation tests made on admission were positive in about two thirds of the patients. Cultures for gonococci were not available to

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