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December 1938

ACTION OF ERGOSTEROL AND OF PURIFIED VITAMIN D ON POLIOMYELITIS VIRUS

Author Affiliations

CLEVELAND
From the Department of Pediatrics of Western Reserve University and the Division of Contagious Diseases of City Hospital.

Am J Dis Child. 1938;56(6):1274-1279. doi:10.1001/archpedi.1938.01980180088007
Abstract

It has been shown that cholesterol inactivates the virus of poliomyelitis either by adsorption or by destruction.1 Cholesterol is derived from animal sources. Perhaps ergosterol would act likewise. The latter is obtained from ergot or yeast and has the same hydrocarbon filament as cholesterol, but with an additional methyl group in the side chain and with two additional double bonds, one in the side chain and the other in the nucleus.

METHODS AND MATERIALS  In the following experiments, the same technic was employed as in previous experiments with cholesterol.1A quantity of a 1 per cent suspension of Flexner's eluted mixed virus2 together with a quantity of ergosterol3 equal in weight to 10 per cent of the total volume used was ground for twelve hours in a ball mill that had been placed in the refrigerator. The test dose was 0.15 cc. of the supernatant fluid

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