In 1930 Moore and Van Slyke1 presented data showing the relation between the plasma protein level and the occurrence of edema in adults with nephritis. Subsequently it was reported by Cowie, Jarvis and Cooperstock,2 in 1930, by Calvin and Goldberg,3 in 1931, and by Mitchell, Rittershofer, Wang, Kaucher, Wing and Hogden,4 in 1938, that in children a somewhat lower protein level is compatible with freedom from edema; but no precise levels were given. In the present series of observations, the relation is shown between the level of the plasma protein, particularly the albumin fraction, and the presence of edema in children with the nephrotic syndrome.
Epstein's view5 has attained general acceptance; he stated that lowering of protein osmotic pressure in the plasma is the chief cause of nephrotic edema. Observation of the plasma protein level is important in assisting one to predict the degree of
FARR LE, VAN SLYKE DD. RELATION BETWEEN PLASMA PROTEIN LEVEL AND EDEMA IN NEPHROTIC CHILDREN. Am J Dis Child. 1939;57(2):306–308. doi:10.1001/archpedi.1939.01990020064005