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Case Reports
May 1939

CHONDRODYSPLASIA: HEREDITARY MULTIPLE CARTILAGINOUS EXOSTOSESREPORT OF FIVE CASES IN A NEGRO FAMILY

Author Affiliations

CHICAGO
From the pediatric service of Provident Hospital.

Am J Dis Child. 1939;57(5):1075-1084. doi:10.1001/archpedi.1939.01990050081009
Abstract

Chondrodysplasia is a comparatively uncommon hereditary osseous dystrophy which usually becomes manifest in infancy or in early childhood. It is characterized by expansion of the ends of the long bones and by multiple cartilaginous and osteocartilaginous growths within and on the skeletal system. These result from a disturbance in growth which affects the proliferation and the ossification of the bone-forming cartilage. The condition is a distinct clinical entity not to be confused with the occasional traumatic or mechanical exostosis found near the epiphysial end of a long bone.

The first case in this country was reported by Gibney1 in 1875; however, the condition received little recognition in America prior to Ehrenfried's2 papers in 1915 and 1917. Stocks3 in 1925 brought the number of total cases reported in the world literature up to 765.

The disease is protean in character: It may manifest itself simply as small cartilaginous

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