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Progress in Pediatrics
November 1939

ROLE OF ACID-SOLUBLE PHOSPHORUS COMPOUNDS IN RED BLOOD CELLSIN EXPERIMENTAL RICKETS, RENAL INSUFFICIENCY, PYLORIC OBSTRUCTION, GASTROENTERITIS, AMMONIUM CHLORIDE ACIDOSIS AND DIABETIC ACIDOSIS

Author Affiliations

CINCINNATI
From the Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati.

Am J Dis Child. 1939;58(5):1072-1089. doi:10.1001/archpedi.1939.01990100154015
Abstract

This discussion of the acid-soluble phosphorus compounds of the red blood cells concerns chiefly their importance in the acid-base equilibrium of the blood and their probable role in the intermediate phosphorus metabolism of the body. It is based on clinical and experimental studies of a variety of conditions in which large changes in the concentration of acid-soluble phosphorus in the blood cells are found. Examples from these studies are presented to demonstrate the changes which have been found associated with rickets, bilateral nephrectomy, alkalosis of pyloric obstruction and different types of acidosis. As a basis for the interpretation of the findings in these conditions, current concepts of the glycolytic cycle in blood are summarized briefly, since the reactions of the glycolytic process are responsible for the synthesis and hydrolysis of the organic phosphorus compounds with which these studies are concerned.

METHODS  Values for inorganic and organic acid-soluble phosphorus were determined

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