In a former publication,1 the need for standardized and well established control of diabetes mellitus in the child was emphasized, not only for the management of the disease but also as a prerequisite for studies concerned with the relative efficacy of varied forms of treatment. It was stated that children with diabetes mellitus showed no consistent qualitative or quantitative difference in response to zinc crystalline insulin and to the amorphous product now commonly used. This report presents a summary of the data which served as a basis for that conclusion.
Subjects used for study were limited to diabetic children whose cases satisfied the following criteria:
Prolonged preliminary observation during which the insulin requirement had become constant for the standard conditions imposed by the therapeutic regimen.
Maintained aglycosuria and freedom from clinically significant insulin shocks.
Approximately normal diurnal blood sugar fluctuations from day to day.
JACKSON RL, BOYD JD, SMITH T. INTERCHANGEABILITY OF ZINC CRYSTALLINE INSULIN AND AMORPHOUS INSULIN. Am J Dis Child. 1940;59(5):1050-1053. doi:10.1001/archpedi.1940.01990160122006