[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.176.30. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Other Articles
June 1940

DURATION OF IMMUNITY TO DIPHTHERIA ACHIEVED BY TOXIN-ANTITOXIN AND ALUM-PRECIPITATED TOXOID

Author Affiliations

EAST ORANGE, N. J.

Am J Dis Child. 1940;59(6):1266-1270. doi:10.1001/archpedi.1940.01990170102007
Abstract

In the year 1932 the use of alum-precipitated toxoid began to supplant the use of toxin-antitoxin and fluid toxoid for immunization against diphtheria. The simplicity of the single injection, its freedom from reactions in young children and the rapid development of immunity appealed to physicians and public health officials. It was assumed that the duration of the immunity was the same as that obtained by toxin-antitoxin, which Park and his co-workers had found to be ten years or more in 80 per cent of cases.1 Recently, however, several reports have appeared in the literature which suggest that the persistence of immunity (as determined by a negative Schick test) produced by alum-precipitated toxoid is not so long as was previously believed, although there are also other reports indicating the persistence of a high degree of immunity. A search of the literature has not revealed any studies covering over three years.

First Page Preview View Large
First page PDF preview
First page PDF preview
×