A study of the Schilling blood counts of a series of children ill with various acute infections disclosed that this form of differential smear is extremely significant in interpreting the clinical progress of the underlying pathologic conditions.1 Thus, when repeated at frequent intervals during the course of an acute infection, this count was shown to anticipate the appearance of a complication, improvement or other change twenty-four hours or more in advance of its appearance clinically.
Shortly after that study a similar one was made in which the examination of the blood smear was limited to cases of acute pneumonia in the young.2 Among these were 31 cases of lobar pneumonia. Daily changes in the differential count were noted with special reference to the immature granulocytes present. It was observed that the percentage of these nonfilamented, "band" forms was markedly increased during the height of the fever and that
ROGATZ JL. SCHILLING BLOOD COUNT IN JUVENILE LOBAR PNEUMONIA TREATED WITH SULFAPYRIDINEPRELIMINARY REPORT. Am J Dis Child. 1940;60(3):501–508. doi:10.1001/archpedi.1940.02000030033002