[Skip to Content]
[Skip to Content Landing]
Other Articles
October 1940


Am J Dis Child. 1940;60(4):812-826. doi:10.1001/archpedi.1940.02000040031003

As hemolytic anemia manifests itself only rarely in early infancy and because the symptoms and progress differ when it does so appear, I have deemed it worth while to attempt to point out the essential features of this disease entity when seen at an early age.

In 1 of the 3 cases here reported symptoms were noted at birth, and in the other 2, at 4 months of age. In none of the 3 could a familial history be obtained.

The following descriptive terms for this condition have been noted in the literature: congenital acholuric jaundice; splenomegalic icterus, Hayem; congenital family cholemia; congenital hemolytic icterus; congenital hemolytic anemia, and congenital or familial hemolytic disease. The Minkowski-Chauffard type is the familial or congenital type; it was first classed as a clinical entity by Minkowski1 in 1900, and in 1907 Chauffard2 linked this condition with lowering of erythrocytic resistance. The

First Page Preview View Large
First page PDF preview
First page PDF preview