The adrenogenital syndrome in children has been described and reviewed repeatedly (Bullock and Sequeria;1 Glynn;2 Reilly, Lisser and Hinman3). Most observers have been especially interested in the sexual precocity or pseudoprecocity caused by hypertrophy, adenoma or cancer of the adrenal cortex. Useful hypotheses have been advanced to explain the syndrome (Krabbe,4 Grollman5), and progress has been made in its early diagnosis and treatment; but with few exceptions (Weber;6 Guthrie and Emery7) little attention has been given to other symptoms which frequently accompany this form of precocity or pseudoprecocity.
Obesity and elevation of blood pressure were the outstanding symptoms in a child with an adrenocortical tumor observed by us. It seems worth while to direct special attention to these symptoms, in view of the physiologic, pathologic and diagnostic problems involved.
Adrenocortical obesity is relatively rare in children, but it is of great general interest
MARKS TM, THOMAS JM, WARKANY J. ADRENOCORTICAL OBESITY IN CHILDREN. Am J Dis Child. 1940;60(4):923-942. doi:10.1001/archpedi.1940.02000040142013