Considerable interest in human dwarfism of the hypophysial type has been stimulated by isolation of the growth hormone. The use of preparations of the anterior lobe of the pituitary containing the growthpromoting principle in children with varyingly subnormal rates of growth has met with indifferent results. Children exhibiting sexual infantilism and defective growth (Lorain-Lévi dwarfs) may be normal at birth and develop adequately until some time in childhood, when growth either ceases or becomes retarded. The arrest involves no special organs and produces a diminutive child whose proportions are normal. The genital retardation is probably not in excess of that of the physical development, but the secondary sexual characteristics are markedly delayed or absent. The mentality may be normal, although the behavior is often immature.
This type of dwarf, as a general rule, is osteologically normal, although the skeletal framework is small. No gross evidence of dystrophy of the bones
BRONSTEIN IP, FABRICANT ND. PITUITARY DWARFISM WITH ATROPHIC RHINITIS. Am J Dis Child. 1940;60(5):1140-1146. doi:10.1001/archpedi.1940.02000050124011