The work of Goldblatt and his associates,1 as well as that of others, has focused attention on the role of ischemia of the kidneys, and particularly on the role of ischemia of a single kidney in the production of arterial hypertension. After this experimental work, attempts have been made to correct hypertension in patients in whom disease has resulted in destruction of a major portion of one kidney. In these attempts nephrectomy has been carried out chiefly because of the presence of hypertension rather than because of the existence of any other indication for surgical treatment.
In 1937, Butler2 made a study of the relation of hypertension to pyelonephritis in children. He studied the records of 15 cases in which the patients were 3 to 11 years of age and in which evidence of pyelonephritis had been demonstrated at necropsy. Records of the blood pressures were inadequate in
KENNEDY RLJ, BARKER NW, WALTERS W. MALIGNANT HYPERTENSION IN A CHILDCURE FOLLOWING NEPHRECTOMY. Am J Dis Child. 1941;61(1):128–134. doi:10.1001/archpedi.1941.02000070137012