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April 1941

PRIMOGENITURE AS AN ETIOLOGIC FACTOR IN PYLORIC STENOSIS

Author Affiliations

TORONTO, CANADA
From the Departments of Biology, Epidemiology and Biometrics of the University of Toronto and the Department of Pediatrics of the Hospital for Sick Children.

Am J Dis Child. 1941;61(4):747-751. doi:10.1001/archpedi.1941.02000100081009
Abstract

A survey of the cases of 436 patients with pyloric stenosis admitted over a period of twenty-five years, 1914 to 1939, to the Hospital for Sick Children in Toronto shows that 50 per cent of the 405 affected infants whose order of birth was known were first-born children. Still,1 in 1927, on the basis of a study of 400 cases of pyloric stenosis gave a comparable figure of 48.5 per cent for the incidence of the disease in first-born children, and Penrose2 cited the figures of 49 and 58 per cent from two studies, one of 221 and the other of 222 cases. Since pyloric stenosis has a genetic basis (Cockayne,3 Sheldon4 and Ford, McCreary and Brown5), and occurs more commonly in males (in 81.8 per cent of the cases in Toronto5), it is important to weigh the evidence for the importance of the

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