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There are a great many problems concerned with the clinical use of vitamin K which still remain unsolved, but there are enough data accumulated to justify a monograph of this type, which summarizes present knowledge. The author shows not only a comprehensive knowledge of the literature in this field but personal experience born of careful laboratory investigation and clinical observation. The monograph covers every aspect of vitamin K.
In the opening chapter the history of the discovery of vitamin K is related, and the work of Dam is cited as having laid the groundwork for the isolation and chemical identification of vitamin K. Other contemporary work is also reviewed. In the next chapter the author discusses the quantitative determination of vitamin K by the indirect methods for measuring prothrombin clotting time. The preventive methods of Almquist and others are briefly sketched, and the question of expressing the values in units
Das Vitamin K und seine klinische Bedeutung.. Am J Dis Child. 1941;62(3):689-690. doi:10.1001/archpedi.1941.02000150213025