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January 1942

MENINGITIS DUE TO ESCHERICHIA COLIREPORT OF TWO CASES WITH RECOVERY FOLLOWING CHEMOTHERAPY, REVIEW OF THE LITERATURE AND REPORT OF EXPERIMENTAL STUDIES

Author Affiliations

BOSTON
From the Robert Dawson Evans Memorial and the John C. Haynes Memorial, of the Massachusetts Memorial Hospitals, and the Departments of Pathology and Medicine, Boston University School of Medicine.

Am J Dis Child. 1942;63(1):41-59. doi:10.1001/archpedi.1942.02010010042004
Abstract

Meningitis caused by the coli-aerogenes group of organisms occurs not too infrequently, and it is therefore somewhat surprising to find that little has been added to the knowledge of this disease since Macaigne1 reviewed 5 cases in 1892. The lack of interest in this type of meningitis is even more difficult to understand in view of the fact that considerable progress has been made in the treatment of other types of meningitis. The failure to report in detail the history and clinical course of the illness, as well as the inadequacy of the available bacteriologic data, may be in part responsible for this apparent lack of interest.

Meningitis due to the colon bacillus has almost invariably been fatal in the past. It seemed desirable, therefore, to review the available case reports in the literature, to add 2 cases in which recovery followed the administration of sulfanilamide and some of

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