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May 1942

ERYTHROBLASTIC ANEMIA FOLLOWING SPLENECTOMY IN CASES OF CHRONIC FAMILIAL HEMOLYTIC ANEMIA

Author Affiliations

MANILA, PHILIPPINE ISLANDS
From the Department of Pediatrics, College of Medicine, University of the Philippines.

Am J Dis Child. 1942;63(5):859-874. doi:10.1001/archpedi.1942.02010050023003
Abstract

Splenectomy is claimed to be the best treatment of chronic hemolytic anemia. W. J. Mayo1 said in 1916, "No other operation I know gives me more brilliant and striking results," and, again, in 1923, "The patient's improvement is little short of marvelous." In several cases of chronic hemolytic anemia that we have studied in which splenectomy was performed, the patient made a full recovery. In the last years, however, splenectomy has not given uniformly good results. W. P. Thompson2 classified hemolytic jaundice into a typical and an atypical variety. Typical hemolytic jaundice is characterized by spherocytosis with increased fragility of the red cells. This variety responds well to splenectomy. Atypical hemolytic jaundice is characterized by absence both of spherocytosis and of increased fragility of the red cells. This variety does not respond well to splenectomy. In 1927 Roth3 published a case in which in spite of splenectomy

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