By Professor Dr. G. Franconi, Direktor der Universitätskinderklinik, Zürich. Price, RM 7.20. Pp. 160, with 21 illustrations. Leipzig: George Thieme, 1941.
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This small book, of 160 pages, is a scholarly presentation of a subject of far reaching practical importance. The author's particular interest in vitamin K was inspired by the observation of hemorrhagic disturbances in certain cases of celiac disease several years ago. These disturbances, he concluded, were due to hypothrombinemia, which he could not then explain. With the discovery that vitamin K, a fat-soluble vitamin produced in the intestinal canal by bacterial action, is necessary for the synthesis of prothrombin in the liver, the answer was clear. The child with severe celiac disease was unable, on account of defective fat digestion, to utilize the fat-soluble vitamin K; there resulted inadequate prothrombin synthesis and consequently a hemorrhagic tendency. The more recent elaboration of accurate and simple methods of estimating the prothrombin content of the blood plasma, together with the isolation of vitamin K and later its synthetic production, have made possible
Die Störungen der Blutgerinnung beim Kinde mit besonderer Berücksichtigung der K-Vitamins und der Neugeborenenpathologie.. Am J Dis Child. 1942;63(6):1190-1191. doi:10.1001/archpedi.1942.02010060174015