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September 1942

VITAMIN E IN PROGRESSIVE MUSCULAR DYSTROPHYFAILURE OF ORAL ADMINISTRATION IN FIFTEEN CASES

Author Affiliations

MINNEAPOLIS

Am J Dis Child. 1942;64(3):455-461. doi:10.1001/archpedi.1942.02010090057005
Abstract

Progressive muscular dystrophy is a disorder of muscle presumed to be due to some primary degenerative process within the muscle tissue itself rather than to be a disturbance secondary to a lesion of the nervous system. The term includes a number of variations in type; the affected muscles in many instances are enlarged (pseudohypertrophic) but in others are normal or even atrophic in appearance. The cause of the condition is unknown, but the hereditary and familial occurrence are noteworthy. As its name indicates, the disease is distinguished by progressive weakness of the skeletal musculature, making its appearance, as a rule, in early childhood. The progress is slow in some cases but usually is rapid, and the disease is often fatal in early life. Unpreventable deformities of the extremities frequently interfere with walking long before the actual loss of muscle power would prevent locomotion. The pathologic effects of the disease appear

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