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Case Reports
October 1942

SPONTANEOUS AND HEREDITARY THROMBOPENIC PURPURA IN A MOTHER AND TWO SONS

Author Affiliations

BROOKLYN
From the Department of Pediatrics and the Department of Medicine of The Brooklyn Hospital.

Am J Dis Child. 1942;64(4):705-713. doi:10.1001/archpedi.1942.02010100131013
Abstract

It is the purpose of this paper to present evidence supporting the concept of congenital thrombopenia as demonstrated by the case of a woman who had a splenectomy for thrombopenic purpura at the age of 14 years. The patient was twice pregnant and had two deliveries. Both children were male, and both succumbed to thrombopenic purpura in the neonatal period. Although the proved cases of congenital thrombopenia are so few as to make one consider it a relatively rare condition, it is probably more common than has been supposed. We believe this is the first report of its occurrence in two children of the same mother and as a result of two consecutive pregnancies.

In 1925 Rushmore1 reported on purpura as a complication of pregnancy. He collected 6 cases in which the fetus showed symptoms similar to those of the mother and added a case of his own. Since

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