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November 1942

STUDIES ON BLOOD PHOSPHORUSIII. INTRACELLULAR AND EXTRACELLULAR BLOOD PHOSPHORUS IN ANEMIA IN CHILDREN AND IN EXPERIMENTAL ANEMIA

Author Affiliations

NEW YORK
From the Pediatric Laboratory and the Department of Pediatrics, New York Post-Graduate Medical School and Hospital, Columbia University.

Am J Dis Child. 1942;64(5):789-802. doi:10.1001/archpedi.1942.02010110021002
Abstract

Few facts are available concerning the distribution of phosphorus in the blood of patients with anemia. The most remarkable contribution was made by Farmer and Maizels,1 who found an enormous increase of the acid-soluble fraction in microcytic hypochromic anemia in adults. Their conclusions are of considerable theoretic interest and will be analyzed later. The results of other investigators (Warweg and Stearns,2 Euler and Brandt,3 Kinzel,4 Kirk5) are less conclusive but give the impression that some peculiar changes in the distribution of phosphorus may be present in anemic conditions. Of these publications only those of Warweg and Stearns2 and Kinzel4 refer to the organic blood phosphorus. To my knowledge the only estimate of the partition of organic phosphorus in anemic children has been made by Kinzel. I studied the extracellular and intracellular blood phosphorus in different forms of anemia in childhood. In addition, I

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