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April 1943

OUTPUT OF BILE PIGMENT BY NEWBORN INFANTS AND BY OLDER INFANTS AND CHILDREN

Author Affiliations

MEDICAL CORPS, ARMY OF THE UNITED STATES; BOSTON
From the Blood Laboratory of the Boston Dispensary, the Boston Floating Hospital, and the J. H. Pratt Diagnostic Hospital; aided by grants from the Charlton Fund, Tufts College Medical School, and Mead Johnson and Company.

Am J Dis Child. 1943;65(4):558-570. doi:10.1001/archpedi.1943.02010160042005
Abstract

In the diagnosis and follow-up of various hematologic and hepatic disorders, determinations of the fecal and urinary outputs of urobilinogen have often proved invaluable. In our own investigations this has been particularly true in the study of the hemolytic syndromes and in the differential diagnosis of hemolytic conditions from hepatic.1 Although our study was at first largely confined to adults, the investigations which are the subject of this report have shown that these determinations are equally valuable in infancy and in childhood.

Determinations of the bile pigments in the stools of infants and of children have only occasionally been performed. This is particularly true in the case of the fecal urobilinogen. Estimations of the bilirubin output have been more frequent, but the actual time of the disappearance of bilirubin from the newborn infant's stool has been but little studied. In most communications, little or no attention has been paid

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