Additional information regarding the familial character of fibrocystic disease is afforded by a family in which this condition was proved to occur in 2 children and probably occurred in 3.
Many instances are on record of the deaths of 2 siblings as a result of this condition. A brief review of 120 cases of fibrocystic disease which have been reported has revealed 12 families in each of which 2 children were affected. Andersen1 stated, "The disease is proved to have occurred more than once in 3 of 23 families and may have occurred in 5 more." Two of the 3 instances Andersen referred to involved siblings who were not twins and 1 involved twins; the last case was cited from Blackfan and Wolbach.2 The twins, who died of the disease, were of the same sex, but it is not known whether they were identical. Blackfan and May described
HOWARD PJ. FAMILIAL CHARACTER OF FIBROCYSTIC DISEASE OF THE PANCREAS. Am J Dis Child. 1944;68(5):330-332. doi:10.1001/archpedi.1944.02020110031007