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February 1945

IMMUNITY TO TETANUS INDUCED BY A THIRD DOSE OF TOXOID FOUR YEARS AFTER BASIC IMMUNIZATIONBASED ON A STUDY OF TWENTY-FIVE ALLERGIC CHILDREN

Author Affiliations

NEW YORK
From the Children's Allergy Clinic, Mount Sinai Hospital: Dr. Murray H. Bass, Director of the Department of Pediatrics.

Am J Dis Child. 1945;69(2):83-88. doi:10.1001/archpedi.1945.02020140015002
Abstract

The increased interest of the medical profession in active immunization against tetanus has been due to the negligible incidence of tetanus among the immunized soldiers engaged in the present world conflict. Of special practical importance is the degree of immunity induced by the "booster" dose of tetanus toxoid in relation to the interval between basic immunization and administration of the "booster" dose.

In my first report,1 on the appearance of tetanus antitoxin in the blood serum following two injections of 0.5 cc. each of combined alumprecipitated diphtheria and tetanus toxoids, it was shown that 94.6 per cent of a group of 186 allergic children acquired a protective level of tetanus antitoxin when 0.01 American unit of antitoxin per cubic centimeter of blood was considered a critical level. In a second study2 a third, or "booster," injection, of 0.5 cc. of the combined toxoids, was given to 65 of

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