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April 1945

TREATMENT OF THE RAT BITE FEVERS WITH PENICILLIN

Author Affiliations

DETROIT
From the Children's Hospital of Michigan and the Department of Pediatrics, Wayne University College of Medicine.

Am J Dis Child. 1945;69(4):215-220. doi:10.1001/archpedi.1945.02020160015003
Abstract

The subject of the rat-bite fevers has been ably reviewed recently by Brown and Nunemaker.1 These writers and others (Albritten and associates2 and Kato3 have stressed the fact that there are two rat-bite fevers: one caused by Spirillum minus and the other by Streptobacillus moniliformis. S. minus has been isolated from the blood of patients with rat-bite fever (sodoku) by inoculation of guinea pigs and mice but has never been satisfactorily cultivated in vitro. Streptobacillus moniliformis, on the other hand, has been cultured from the blood of patients with the other type of rat-bite fever by use of special technics. Brown and Nunemaker showed that the symptoms and course of the two diseases may be extremely similar, although other authors (Rosen and Denzer,4 Larson,5 and Albritten and associates) have asserted that characteristic differential features exist. Since methods for isolation of S. moniliformis have been publicized,

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