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August 1945

PATHOGENESIS OF NEPHROTIC HYPERLIPEMIA

Author Affiliations

CLEVELAND; MEDICAL CORPS, ARMY OF THE UNITED STATES
From the Babies and Childrens Hospital and Western Reserve University School of Medicine, Cleveland.

Am J Dis Child. 1945;70(2):74-82. doi:10.1001/archpedi.1945.02020200016002
Abstract

The purpose of the experiments reported herein was to study the endogenous mechanism which controls blood lipid concentration and to obtain knowledge which might explain the mechanism which increases the blood lipids in "lipemic nephrosis."

The endogenous origin of the hyperlipemia of nephrosis is shown by the fact that the condition is not affected by exogenous lipids.1 It is also known that this increase in lipids is not due to a disturbance in the oxidation of fat.2 The two hypotheses which try to explain the pathogenesis of the hyperlipemia of nephrosis (a) on the basis of the hypoproteinemia3 and (b) as a primary disturbance of lipid metabolism4 are insufficiently supported by experimental or clinical evidence.5 Observations on children suffering from nephrosis suggested that the kidneys may exert some regulating influence on the blood lipid concentration and that nephrotic hyperlipemia may result from a disturbance of

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