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Causes of Prematurity
November 1945


Author Affiliations

From the Children's Hospital Research Foundation and the Department of Pediatrics, University of Cincinnati, College of Medicine.

Am J Dis Child. 1945;70(5):318-324. doi:10.1001/archpedi.1945.02020230058010

The importance of maternal syphilis as a cause of premature delivery has always been difficult to assess because of several factors which may influence the interpretation of the data. Among these factors are the amount of antisyphilitic treatment the patients have received and the possibility of coexistent diseases which may also induce premature labor. In our previous study1 the influence of syphilis as a causative factor of prematurity seemed to be of doubtful significance. Since that time more patients have been added to the series, and we have been able to make a more detailed analysis of the subject. These patients could be divided into groups; one composed of women who had no detectable illness of any kind during pregnancy; another including those whose only illness was syphilis, and, finally, groups of women who had other prenatal abnormalities associated with syphilis. The incidence of prematurity among the offspring of

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