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Pathogenesis of Congenital Hemolytic Disease (Erythroblastosis Fetalis)
January 1946

II. Illustrative Case Histories of Rh Sensitization

Author Affiliations

From the Serologic Laboratory of the Office of the Chief Medical Examiner of New York City and the Transfusion Division, Jewish Hospital of Brooklyn.

Am J Dis Child. 1946;71(1):25-40. doi:10.1001/archpedi.1946.02020240032003

IN THE preceding paper, a comprehensive hypothesis of the pathogenesis of congenital hemolytic disease was proposed.1 In this paper, we shall present a number of illustrative case histories in which sensitization to the Rh factor was the cause of the disease, and at the same time we shall indicate the application of the hypothesis as an aid in the diagnosis, prognosis and treatment of the disease. The cases presented here make up only a small fraction of our clinical material, but they are representative of the various problems that may be encountered when treating congenital hemolytic disease.

REPORT OF CASES  Case 1.—This patient was referred to us by Dr. B. Merriam, with the history that she was in the eighth month of pregnancy and that no fetal heart sounds had been audible for the past three weeks. This was the patient's third pregnancy. The first pregnancy had terminated with

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