RECENT reviews of congenital hemolytic anemia in childhood have been published by Abt, Debré, Diamond and others,1 all of whom emphasize the mild and atypical manifestations in early infancy.
This disease has been recognized by the third day of life (Hawksley2), the diagnosis having been made on the basis of family history, increased fragility of the red blood cells and microcytosis. However, jaundice and splenomegaly did not appear until the infant was over a month of age.
The following report of a case is presented because of the early age at which the classical evidence of congenital hemolytic anemia appeared, necessitating the patient's admission to the hospital at the age of 17 days, followed by splenectomy at 10 weeks.
REPORT OF A CASE
History.—L. P., a 17 day old white boy, was admitted to Duke Hospital Sept. 6, 1945, because of jaundice of two days' duration. He
CONRAD E, SCHMIDT RE. CONGENITAL HEMOLYTIC ANEMIA—A CASE REQUIRING EARLY SPLENECTOMY. Am J Dis Child. 1946;72(6):731–733. doi:10.1001/archpedi.1946.02020350098008