Book Reviews
December 1947

The Biology of Stomach Kathepsin.

Author Affiliations

By Dr. Med. S. Buchs. Price, 12 Swiss francs. Pp. 79, with 60 illustrations. Basel, Switzerland: S. Karger, 1947.

Am J Dis Child. 1947;74(6):749-750. doi:10.1001/archpedi.1947.02030010767014

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This monograph gives an excellent description of protein digestion in the stomach and does so in a manner which is instructive for the specialist in this field and yet understandable for the reader not specially trained. The first part of the book tries to prove the existence and to establish the identity of kathepsin as part of the enzyme system of the stomach. The discrepancy of the optimal acidity for pepsin action and the actual acidity of the chymus demand as explanation for the digestive process a second enzyme with the optimal activity more on the alkaline side. The author describes an accurate method of measuring the digestive process and then proceeds to analyze this "second ferment" as to its characteristics. He studies the enzyme action under different hydrogen ion concentrations and temperatures and under the influence of irradiation or activating or inhibiting substances. In the next chapter the action

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