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January 1948


Author Affiliations

From the Department of Pediatrics, Western Reserve University School of Medicine, and the Babies and Childrens Hospital, University Hospitals of Cleveland. This study was aided by a grant from the John and Mary R. Markle Foundation.

Am J Dis Child. 1948;75(1):68-75. doi:10.1001/archpedi.1948.02030020075007

SEVERE hydropic degeneration of the kidneys, usually limited to the proximal convoluted tubules and the ascending loop of Henle, has been observed after intravenous administration of hypertonic solutions of sucrose in rabbits and men. Helmholtz1 reported this condition first in 1933, and numerous investigators2 subsequently confirmed his observations. Experimental evidence3 has been obtained which suggests that impairment of function of the renal tubules in dogs, cats, rats and monkeys disturbs the balance of factors regulating the concentration of lipids in the blood. It was the object of this study to investigate whether hydropic degeneration of renal tubules, produced by intravenous and intraperitoneal administration of hypertonic solutions of sucrose, is followed by hyperlipemia.

METHODS  The chemical methods used in this study have been described previously.3a Male dogs were maintained on a "dog chow" ration and were fed bones once a week. On the evening prior to the

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