Case Reports
May 1948


Author Affiliations

Resident in Medicine at the Children's Memorial Hospital SANTIAGO, CHILE; MONTREAL, CANADA
From the Children's Memorial Hospital, Montreal, Canada; Physician in Chief, Dr. Alton Goldbloom.

Am J Dis Child. 1948;75(5):695-701. doi:10.1001/archpedi.1948.02030020712005

IN 1922 Stevens and Johnson reported 2 cases under the title "an eruptive fever with stomatitis and ophthalmia."1 These patients were boys 7 and 8 years of age, and in both children after a period of three to four weeks the temperature fell to normal, the cutaneous lesions disappeared and the general condition improved. The sequelae were in 1 instance a severe corneal ulcer and in the other bilateral panophthalmitis with destruction of the cornea and lens.

The combination of cutaneous lesions, involvement of the mucous membranes and severe constitutional symptoms was first reported in medical literature in 1822 by Alibert and Bazin.2 Von Hebra in 1866, in his original description of erythema multiforme bullosa, also mentioned cases with conjunctival and oral changes.3 In the subsequent years many authors, unfortunately, reported cases with similar symptoms under various names. Hence, "ectodermose erosive pluriorificielle,"4 "dermatostomatitis,"5 "Stevens-Johnson disease,"

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