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Case Reports
June 1948

EOSINOPHILIC GRANULOMA OF BONEReport of Three Cases

Author Affiliations

NEW YORK; NEWARK, N. J.
From the orthopedic service of Dr. A. H. Bingham and the pediatric service of Dr. R. A. Benson, New York Medical College, Flower and Fifth Avenue Hospitals, and the service of Dr. Leo Mayer, Hospital for Joint Diseases.

Am J Dis Child. 1948;75(6):900-909. doi:10.1001/archpedi.1948.02030020918010
Abstract

EOSINOPHILIC GRANULOMA of bone was first described as a separate clinical entity by Lichtenstein and Jaffe in 1940. They reported 10 cases. Independently of these investigators, Otani and Ehrlich reported cases showing the same type of lesion, which they named "solitary granuloma of bone." At first, eosinophilic granuloma was thought to be a solitary bone lesion. Later on, however, typical cases of multiple skeletal involvement were observed. Apparently, eosinophilic granuloma of bone had also been observed by earlier investigators, who described it as "myeloma with prevalence of eosinophilic cells" (Finzi) or "osteomyelitis with eosinophilic reaction" (Schairer 1944). Jaffe and Lichtenstein, in their latest publication in 1944, reported that they... found the lesion to be characterized histologically by conspicuous sheetlike collections of histiocytes (including some revealing phagocytic activity), interspersed among which there were more or less prominent accumulations of eosinophilic cells and especially eosinophilic leukocytes. In addition, however, we usually also

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