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Case Reports
July 1948

AGENESIS OF CORPUS CALLOSUM IN INFANCY: CLINICAL AND ROENTGENOLOGIC ASPECTS

Author Affiliations

NEW YORK
From the Neuropsychiatric and Pediatric Services, Morrisania City Hospital.

Am J Dis Child. 1948;76(1):109-115. doi:10.1001/archpedi.1948.02030030116013
Abstract

CONGENITAL ABSENCE of the corpus callosum and the anomalies that occur in association with this condition have been the subjects of many studies since the first description of this entity by Reil1 in 1812. In 1922 Mingazzini2 collected 71 cases in his classic monograph on the corpus callosum. Baker and Graves3 in 1933 collected an additional 11 cases. To date, well over 100 cases have been reported. Until 1934 it was uniformly recorded as an incidental observation at necropsy. Davidoff and Dyke4 and Penfield and Hyndman5 were the first to establish the criteria for the pneumoencephalographic diagnosis of agenesis of the corpus callosum. Twenty-two cases have been diagnosed by roentgenologic means, 10 of which were confirmed by necropsy studies or at operation. More adequate opportunities were thus afforded for accurate study of the clinical aspects of these cases and for better classification of some of

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