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Case Reports
September 1948

ASEPTIC MENINGITIS FOLLOWING IMMUNIZATION WITH DIPHTHERIA TOXOID

Author Affiliations

ATLANTA, GA.
From the Medical Service, Grady Hospital, and the Department of Medicine, Emory University School of Medicine.

Am J Dis Child. 1948;76(3):331-333. doi:10.1001/archpedi.1948.02030030341006
Abstract

THE OCCURRENCE of a neurologic complication during the course of immunization against diphtheria with toxoid is most unusual. A review of the literature revealed a report by Schioppa1 of a case of transitory paralysis of the palate following immunization with diphtheria toxoid. The present case is 1 in which aseptic meningitis occurred during immunization with diphtheria toxoid.

REPORT OF A CASE  B. A. was an 18 year old white nurse in training at another hospital. Her reaction to the Schick test was found to be positive; consequently, she was started on a course of immunization with diphtheria toxoid. Because of a strong reaction to the Moloney test, the course of immunization was begun cautiously. On Sept. 19, 1946, she received 0.05 cc. of toxoid, the inoculation being followed by a severe local reaction. Therefore, the second dose, seven days later, was not increased, and this time she had only

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