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October 1948

OCCURRENCE OF COMPLICATIONS IN SCARLET FEVER TREATED WITH PENICILLIN, ANTITOXIN AND GAMMA GLOBULIN

Am J Dis Child. 1948;76(4):380-383. doi:10.1001/archpedi.1948.02030030392002

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Abstract

PREVIOUS experience in 1944-1945 with gamma globulin as a therapeutice agent in scarlet fever indicated that this product of human blood was useful in combating the acute phase of the disease and in preventing early and late complications. It was felt, however, that further, more carefully controlled, studies on the comparative value of gamma globulin, scarlet fever streptococcus antitoxin U. S. P. and penicillin should be made. This paper represents the results of such a study at the Willard Parker Hospital during 1945 and 1946 on 245 patients with scarlet fever. Of these patients, the illness of 93 was graded as mild, that of 127 as moderate and that of 18 as severe (table 1). No patient who did not have a culture of material from the throat yielding hemolytic (beta) streptococci was included in the study. Only 18 per cent of the throat cultures of the patients treated with

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