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March 1949

SEVERE ERYTHROBLASTOSIS FETALIS AND ICTERUS PRECOXOccurrence of Both Diseases in the Same Family

Author Affiliations

Hematologist, Norwegian Hospital BROOKLYN

Am J Dis Child. 1949;77(3):351-354. doi:10.1001/archpedi.1949.02030040361006
Abstract

SINCE the literature is replete with evidence attesting to the etiologic role of the Rh factor in the pathogenesis of erythroblastosis fetalis in 90 per cent of the cases, it seems needless in this paper to dilate further on this subject. It is not generally recognized, however, that the A and B factors may also cause erythroblastosis fetalis,1 cases of which Halbrecht2 designated as icterus precox. In the case that will be reported here sensitization to the B factor was responsible for icterus precox three times in the same family. Moreover, the woman in question also had 2 full term babies with icterus gravis, both of whom died within three days, in spite of transfusions.

REPORT OF CASES  E. B., a quintipara, was referred to me because she had lost the second and fourth babies with icterus gravis, while the first, third and fifth babies survived. She was

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