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June 1949

STREPTOMYCIN THERAPY IN TUBERCULOUS MENINGITIS

Author Affiliations

CHICAGO
From the Children's Division of the Cook County Hospital and the Hektoen Institute for Medical Research of the Cook County Hospital.

Am J Dis Child. 1949;77(6):709-728. doi:10.1001/archpedi.1949.02030040724002
Abstract

IN ATTEMPTING to evaluate my results with streptomycin, I shall take into consideration the immediate clinical response, the subsequent course of the disease, the frequency of complications, the occurrence of relapses and the length of time the patient remained alive.

In addition to the study of the effects of streptomycin, I shall report on the cerebrospinal fluid changes, before, during and after treatment and also on the streptomycin levels in the blood and cerebrospinal fluid.

I should like to call particular attention to the fact that, with the exception of 1 patient who received streptomycin intrathecally for nine days, all these patients received streptomycin intramuscularly only.

I treated 19 patients, whose ages ranged from 6 months to 13 years. There were 10 boys and 9 girls; 15 were Negro, 3 Mexican and 1 white. The preponderance of Negroes among this series may be explained by the fact that a large

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