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November 1949

AGGLUTINATING SUBSTANCES FOR HOMOLOGOUS COLIFORM ORGANISMSObservations on Their Occurrence in the Serum and Feces of Infants

Author Affiliations

From the Department of Pediatrics, Yale University School of Medicine, and the University Service, Grace-New Haven Community Hospital.

Am J Dis Child. 1949;78(5):717-727. doi:10.1001/archpedi.1949.02030050734009

THE PATHOGENICITY of coliform organisms is most commonly recognizable in infections of the urinary tract. Siede and Luz1 observed that 80 per cent of 63 patients with disease of this nature exhibited elevated serum agglutinins (> 1:80) for homologous strains of coliform bacilli nine days or more after the onset of illness. Although the possibility has been suggested that coliform organisms might similarly be concerned in the pathogenesis of infantile diarrhea, no conclusive evidence on the subject has appeared. Ruchman and Dodd2 recently observed that during the course of illness there occurred a rise in titer of serum agglutinins for a homologous coliform organism isolated from a patient with infantile diarrhea.

The occurrence of agglutinating substances for dysentery bacilli in the feces of patients with dysentery was noted by several investigators.3 Harrison and Banvard3a observed that the fecal agglutinin titer rose rapidly in such patients during

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