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Case Reports
January 1950

ESCHERICHIA COLI MENINGITIS TREATED SUCCESSFULLY WITH STREPTOMYCIN

Author Affiliations

Professor of Pediatrics, University of Salonika; SALONIKA, GREECE

Am J Dis Child. 1950;79(1):115-116. doi:10.1001/archpedi.1950.04040010125015
Abstract

ESCHERICHIA coli meningitis is rather unusual. It is observed particularly in newborn children, who, according to Scherer1 are infected through a bacillemia. Cases in infants, 2 months old, were observed by Reinhardtla and Navarro.1b Navarro stated that until 1929 he had found in the literature only 18 cases of E. coli meningitis in children. It is also reported as occurring during infancy subsequent to gastric disturbances.2 The spinal fluid is not clear but usually purulent.

The mortality rate of reported cases of this disease is high. Bardisian,3 in seventeen years of his pediatric career, observed only 4 cases and death occurred in all within a few days. It is true that for many years the treatment was more empiric and was unsuccessful, until the discovery of streptomycin and the observation that it exhibited a powerful bacteriostatic activity against many of the gram-negative pathogens.4 After

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