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March 1950


Author Affiliations

From the Pediatric Service of the Bronx Hospital, Dr. Bernard S. Denzer, director (retired).

Am J Dis Child. 1950;79(3):475-486. doi:10.1001/archpedi.1950.04040010488007

HYPERVITAMINOSIS A is a clinical entity which occurs in late infancy and early childhood. The pathologic processes are the result of a prolonged and excessive intake of vitamin A and a derangement of vitamin A metabolism. Clinically, the condition is manifested by anorexia, with loss of weight, extreme irritability and fretfulness, low grade fever, pruriginous rash, sparseness of hair, hepatomegaly and exquisite pain on pressure over the long bones. Biochemically there are abnormally high vitamin A levels in the blood serum and increased levels of the serum lipids. Roentgenographically, the changes in the long bones are distinctive, characterized especially by periosteal proliferation.

A review of the literature uncovered a significant scarcity of these cases. The study of the effects of excessive dosage of vitamin A was limited to experimental animals, until Josephs'1 case report in 1944 revealed the existence of a similar clinical entity in man. His patient was

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